Clinicopathological Significance and Prognostic Role of Her2neu Protein Expression in Patients with Carcinoma Stomach: A Prospective Study from Northern India

Background and Aims Gastric cancer is the third most common cause of cancer-related mortality worldwide after lungs colorectum. Although controversial, Her2neu overexpression by immunohistochemistry usually associated with poor prognosis in patients carcinoma stomach. We conducted a prospective study to evaluate prognostic role its correlation clinical, pathologic type, stage disease. Methods A was performed on paraffin blocks 111 gastric specimens (88 were biopsy 23 gastrectomy specimens). The processed for receptor immunohistochemical staining fluorescence situ hybridization, scoring done. Results detected 30 out (27%) patients. mean age 57.68 ± 12.82 years, males constituting two-thirds total Tobacco addiction found 44% smoking 33% expression similar Lauren's intestinal diffuse histologic type; however, proximal tumors overexpressed as compared distal tumors. 2+ or 3 + (odds ratio: 2.52, 95% CI: 1.61–3.95, p = 0.001) only independent predictor survival Kaplan–Meir analysis showed that (Her2neu ) significantly lower than those nonexpression (p 0.001). Conclusion positivity significant stomach, overall rate nonexpression.